Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md
Drug-induced acute pancreatitis (e.g., aminosalicylic acid, azathioprine, corticosteroids, dexamethasone, ethacrynic acid, ethanol, furosemide, thiazides, mercaptopurine, phenformin, triamcinolone).
Drug-induced methodologic interference (e.g., pancreozymin [contains amylase], chloride and fluoride salts [enhance amylase activity], lipemic serum [turbidimetric methods]).
Obstruction of pancreatic duct by
Stone or carcinoma
Drug-induced spasm of the sphincter of Oddi (e.g., opiates, codeine, methyl choline, cholinergics, chlorothiazide) to levels 2–15 times normal
Partial obstruction + drug stimulation
Biliary tract disease
Common bile duct obstruction
Acute cholecystitis
Complications of pancreatitis (pseudocyst, ascites, abscess).
Pancreatic trauma (abdominal injury; following ERCP).
Altered GI tract permeability:
Ischemic bowel disease or frank perforation