Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (698 page)

   
Normal range:
10–60 pg/mL.

   Use

   Evaluating hypertension

   Interpretation

Increased In

   Hypertension

   Renin-secreting juxtaglomerular renal tumor

   Volume depletion

   CHF

Decreased In

   Anephric patients

   Primary aldosteronism

   Cushing syndrome

   Limitations

   Patient should be on normal-sodium diet and be recumbent for 30 minutes before specimen collection.

   Short lived in plasma (half-life is 5 minutes) degraded into inactive peptides, plasma should be separated and frozen immediately.