Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (742 page)

   Monitoring the efficacy of neonatal phototherapy

   Interpretation

Increased In

   Hepatocellular damage

   Biliary obstruction

   Hemolytic diseases

   Neonatal physiologic jaundice

   Gilbert disease, Crigler-Najjar syndrome

   Hypothyroidism

   Dubin-Johnson syndrome

   Increased conjugated (direct) bilirubin in

   Hereditary disorders (e.g., Dubin-Johnson syndrome, rotor syndrome).

   Hepatic cellular damage (e.g., viral, toxic, alcohol, drugs). Increased conjugated bilirubin may be associated with normal total bilirubin in up to one third of patients with liver diseases.

   Biliary duct obstruction (extrahepatic or intrahepatic).

   Infiltrations, space-occupying lesions (e.g., metastases, abscess, granulomas, amyloidosis).