CLARITHROMYCIN–MACROLIDE ANTIBIOTIC
Brand Name
Biaxin, Biaxin XL
Uses
Treat bronchitis, otitis media, acute maxillary sinusitis, pharyngitis, tonsillitis, pneumonia, skin infections.
Availability
Suspension: 125/5 mL, 250/5 mL. Tablets: 250 mg, 500 mg. Tablets, extended-release: 500 mg.
Indications/Routes/Dosages
Acute otitis media: Children: 15 mg/kg/day in 2 divided doses for 10 days.
Respiratory/skin infections: Children: 15 mg/kg/day in 2 divided doses for 10 days. Usual adult dose: 250-500 mg q12h for 7-14 days. Extended release: Two 500-mg tablets daily for 7-14 days.
Adverse Reactions
Antibiotic-associated colitis (severe abdominal pain, fever, watery diarrhea), superinfection, hepatotoxicity, thrombocytopenia.
Implications
Monitor bowel activity and stool consistency.
For minor GI effects take with food.
Doses should be evenly spaced.
Take with 8 oz water.
CLINDAMYCIN–ANTIBIOTIC
Brand Name
Cleocin
Uses
Treat infections from staphylococci, streptococci, Rickettsia,
Pneumocystis carinii
pneumonia.
Availability
Oral solution: 75 mg/mL. Capsules: 75 mg, 150 mg, 300 mg.
Indications/Routes/Dosage
Children younger than 1 month: 15-20 mg/kg/day divided q6-8h. Children older than 1 month 8-25 mg/kg/day divided q6-8h. Adult: 150-450 mg q6h. Max 1.8 g/day.
Adverse Reactions
Nausea, vomiting, diarrhea, pseudomembranous colitis (severe diarrhea), urinary frequency, vaginitis.
Implications
Take with full glass of water.
Give with food to reduce GI symptoms.
Antiperistaltic drugs may worsen diarrhea.
Do not break, crush, or chew capsules.
Call provider for diarrhea.
CLOMIPRAMINE HYDROCHLORIDE–TRICYCLIC ANTIDEPRESSANT
Brand Name
Anafranil
Uses
Treat obsessive-compulsive disorder manifested as repetitive tasks producing marked distress; off label: mental depression, panic disorder, neurogenic pain, bulimia.
Availability
Capsules: 25 mg, 50 mg, 75 mg.
Indications/Routes/Dosage
Children: starting dose of 10 mg/day; increase to 75-100 mg/day. Teens: starting dose of 10 mg/day increase to 100-200 mg/day.
Adverse Reactions
Dry mouth, dizziness, sleepiness, tremors, decreased libido, headache, aggressiveness, high doses may produce cardiovascular effects (severe postural hypotension, dizziness, tachycardia, palpitations, arrhythmias, seizures). Abrupt withdrawal from prolonged therapy may produce headache, malaise, nausea, vomiting.
Implications
Contraindicated within 14 days of MAO inhibitor ingestion.
Caution with history of seizures, hyperthyroidism, cardiac/hepatic/renal disease, diabetes mellitus.