Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1002 page)

IMMUNOGLOBULIN D (IgD)

   Definition

   IgD is mainly found on the surface of B cells and may help regulate B-cell function. IgD likely serves as an early B-cell antigen receptor; however, the function of the circulating IgD is largely unknown. IgD functions to activate some lymphocytes.

   
Normal value:
≤15.3 mg/dL.

   Use

   Diagnosis of rare IgD myelomas (greatly increased)

   Interpretation

Increased In

   Monoclonal

   IgD multiple myeloma

   MGUS

   Polyclonal

   Chronic infection (moderately)

   Autoimmune disease

   Acute viral hepatitis

   COPD