Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md
Most causes of hypocalcemia (except vitamin D deficiency, in which it is usually decreased)
Increased tubular reabsorption or decreased glomerular filtration of phosphate
Hypoparathyroidism (idiopathic, surgical, irradiation)
Secondary hyperparathyroidism (renal rickets)
Pseudohypoparathyroidism types I and II
Other endocrine disorders (e.g., Addison disease, acromegaly, hyperthyroidism)
Sickle cell anemia
Increased cellular release of phosphate
Neoplasms (e.g., myelogenous leukemia, lymphomas)
Excessive breakdown of tissue (e.g., chemotherapy for neoplasms, rhabdomyolysis, malignant hyperthermia, lactic acidosis, acute yellow atrophy, thyrotoxicosis)
Bone disease (e.g., healing fractures, multiple myeloma [some patients], Paget disease [some patients], osteolytic metastatic tumor in bone [some patients])
Childhood
Increased phosphate load: exogenous phosphate (oral or IV) form