Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (122 page)

   Atrophic (Type A Gastritis, Autoimmune Type)

   Gastric antrum is spared.

   Parietal cell antibodies and intrinsic factor antibodies help identify those patients prone to pernicious anemia (PA).

   Characteristics include the following:

   Achlorhydria

   Vitamin B
₁₂
–deficient megaloblastosis

   Hypergastrinemia (due to hyperplasia of gastrin-producing cells)

   Gastric carcinoids

   Low serum pepsinogen I concentrations

   Laboratory findings may be due to other accompanying autoimmune diseases (e.g., Hashimoto thyroiditis, Addison disease, Graves disease, myasthenia gravis, hypoparathyroidism, type 1 DM).

   Nonatrophic (Type B Gastritis)

   Gastric antrum is involved.

   Anemia caused by iron deficiency, and malabsorption may occur.