Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (323 page)

   Psychotropic drugs (clozapine, phenothiazines, tricyclic and tetracyclic antidepressants, meprobamate)

   Cardiovascular (procainamide, ticlopidine, ACE inhibitors, propranolol, dipyridamole, digoxin)

   Diuretics (thiazides, furosemide, spironolactone, acetazolamide)

   Antithyroid drugs (thioamides)

   Dermatologic drugs (dapsone, isotretinoin)

   
Chronic idiopathic neutropenia

   
Neonatal and infantile neutropenia

   Maternal immune neutropenia

   Maternal isoimmunization to fetal leukocytes

   
Congenital neutropenia
as seen with certain inborn errors of metabolism and other congenital syndromes

Suggested Reading

Boxer LA. How to approach neutropenia.
Hematology Am Soc Hematol Educ Program.
2012;2012:174–182.

AGRANULOCYTOSIS

Definition

The term agranulocytosis literally means total absence of granulocytes in the peripheral blood. When the neutrophils and bands are <500/μL, the term severe granulocytopenia is used. A count <500/μL confers a high risk for sepsis; a count of <200 is certain to lead to overwhelming bacterial infection.

Agranulocytosis may be the result of

   Peripheral destruction of PMNs (often drug related)

   Bone marrow failure