Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md
Associated with alcohol abuse (AG frequently 20–25 mmol/L)
Starvation (AG usually 5–10 mmol/L)
Drugs
Salicylate poisoning (AG frequently 5–10 mmol/L; higher in children)
Methanol poisoning (AG frequently >20 mmol/L)
Ethylene glycol poisoning (AG frequently >20 mmol/L)
Paraldehyde (AG frequently >20 mmol/L)
With Normal Anion Gap: Hyperchloremic Metabolic Acidosis
Decreased Serum Potassium
Renal tubular acidosis (RTA)
Acquired (e.g., drugs, hypercalcemia)
Inherited (e.g., cystinosis, Wilson disease)
Carbonic anhydrase inhibitors (e.g., acetazolamide, mafenide)
Increased loss of alkaline body fluids (e.g., diarrhea, loss of pancreatic or biliary fluids)
Ureteral diversion (e.g., ileal bladder or ureter, ureterosigmoidostomy)