Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (718 page)

   
Normal value:
negative.

   Use

   Evaluation of patients suspected of having WG or systemic vasculitis, especially patients with renal disease, pulmonary disease, or unexplained multiorgan disease possibly due to vasculitis

   Interpretation

Increased In

   c-ANCA (PR3 positive):

   Systemic necrotizing vasculitis

   Common: WG

   CSS

   May also be seen in systemic necrotizing vasculitis of polyarteritis group, pauci-immune type of idiopathic crescentic glomerulonephritis.

   Propylthiouracil drug

   pANCA (MPO positive):

   Systemic necrotizing vasculitis

   Common: microscopic polyarteritis