Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (734 page)

   Interpretation

   When evaluating concentrations in plasma/serum, effect of multiple active moieties must be considered. When evaluating concentrations in urine, metabolite rather than parent may be detected. Active metabolites are

   Alprazolam: alpha-hydroxy alprazolam

   Flunitrazepam: 7-aminoflunitrazepam

   Midazolam: alphahydroxy and 4-hydroxy midazolam

   Triazolam: alphahydroxy and 4-hydroxy triazolam

   Diazepam: nordiazepam, temazepam, oxazepam

   Chlordiazepoxide: demoxepam, norchlordiazepoxide, nordiazepam, oxazepam

   Temazepam: oxazepam

   Limitations

   Testing: screening by immunoassay for urine and serum

   ELISA (serum)

   Target analyte: temazepam