Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (821 page)

   
Factor IX:
Pregnancy and use of oral contraceptives. Very elevated values have been associated with a tendency to thromboembolism.

   
Factor X:
Pregnancy and use of oral contraceptives.

Decreased In

   
Factor II

   Congenital deficiency (recessive inheritance): Bleeding of various severities in homozygotes

   Acquired deficiency: Liver disease, DIC, pathologic fibrinolysis, vitamin K deficiency, or warfarin therapy

   
Factor V

   Congenital: inherited autosomal deficiency; bleeding in homozygotes

   Acquired: liver disease, DIC, or pathologic fibrinolysis

   
Factor VII

   Congenital deficiency: manifested by variable bleeding in homozygotes

   Acquired: liver disease, vitamin K deficiency, vitamin K antagonist therapy

   
Factor VIII

   Congenital: hemophilia A in male patients and in some female carriers of the hemophilia gene (usually mild decrease); von Willebrand disease, especially if moderate to severe