Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (1055 page)

Increased In

   Leukemoid reaction

   Polycythemia vera and essential thrombocythemia (occasionally it may be normal)

   Idiopathic myelofibrosis

   Pregnancy

   Trisomy 21 and Klinefelter syndrome

Decreased In

   Chronic myeloid leukemia

   PNH and pernicious anemia

   Congenital hypophosphatasia

   Limitations

   Blood that is not processed soon after drawing may cause low LAP scores.

   There is observer-dependent variability.

LIPASE

   Definition

   Glycoprotein enzyme filtered by glomeruli and completely reabsorbed by proximal tubules; method should always include colipase in reagent

   
Normal range:
0–50 U/L