Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md
Intoxicants (e.g., barbiturates, methyl alcohol, ammonia, carbon monoxide); some patients with alcoholism
Decreased renal clearance or tubular secretion (e.g., various diuretics [thiazides, furosemide, ethacrynic acid] and all diuretics except spironolactone and ticrynafen)
Nephrotoxic effect (e.g., mitomycin C)
Low-dose salicylates (<4 g/day)
Other effects (e.g., levodopa, phenytoin sodium)
Metabolic acidosis
Diet
High-protein weight reduction diet
Excess nucleoprotein (e.g., sweetbreads, liver) may increase level ≤1 mg/dL
Alcohol consumption
Miscellaneous
von Gierke disease
Chronic lead poisoning
Lesch-Nyhan syndrome