Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (704 page)

   Prevention and treatment of infections caused by bacteria

   Limitations

   Testing must be performed on serum or plasma.

   Peak concentrations: collect specimen 30–120 minutes after completion of infusion (drug and route dependent).

   Trough concentrations: collect specimen 5–90 minutes before next infusion (drug dependent).

   Testing methodologies: immunoassay (e.g., fluorescence polarization) or HPLC.

   
Specimens must be frozen
for streptomycin and amphotericin B.

   Specimens must be protected from light for trimethoprim and amphotericin.

   Unacceptable specimens:

   Hemolyzed

   Collection tubes with additives such as serum separator, citrate, oxalate, or fluoride

   Trimethoprim may be detected in urine in general toxicology screens utilizing GC/MS.

ANTICARDIOLIPIN ANTIBODIES (ACAs)

   Definition