Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (708 page)

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Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
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CYP2C9
*1 (normal)
   
CYP2C9
*2 (c.430C>T; Arg144Cys)
   
CYP2C9
*3 (c.1075A>C; Ile359Leu)
   
VKORC1
*1 (normal)
   
VKORC1
*2 promoter variant (c.–1639G>A)
   
Normal values:
   
CYP2C9
*1/*1
   
VKORC1
*1/*1
   Use
   Initiating warfarin (Coumadin) therapy
   Optimizing dosing for warfarin
   Limitations
   The results of a genetic test may be affected by DNA rearrangements, blood transfusion, bone marrow transplantation, or rare sequence variations.
ANTICONVULSANTS
*

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