Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (708 page)

   
CYP2C9
*1 (normal)

   
CYP2C9
*2 (c.430C>T; Arg144Cys)

   
CYP2C9
*3 (c.1075A>C; Ile359Leu)

   
VKORC1
*1 (normal)

   
VKORC1
*2 promoter variant (c.–1639G>A)

   
Normal values:

   
CYP2C9
*1/*1

   
VKORC1
*1/*1

   Use

   Initiating warfarin (Coumadin) therapy

   Optimizing dosing for warfarin

   Limitations

   The results of a genetic test may be affected by DNA rearrangements, blood transfusion, bone marrow transplantation, or rare sequence variations.

ANTICONVULSANTS
*