Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (911 page)

   Resistant ovary syndrome

   Toxic (e.g., irradiation, chemotherapy)

   Infection (e.g., mumps)

   Tumor (primary or secondary)

   Mechanical (e.g., trauma, torsion, surgical excision)

   Genetic (e.g., Turner syndrome)

   Menopause

   Secondary hypofunction of the ovary: disorders of the hypothalamic–pituitary axis

ESTRONE

   Definition

   Estrone (E
₁
) is more potent than estriol (E
₃
) but is less potent than estradiol (E
₂
). Estrone is converted to estrone sulfate, and it acts as a reservoir that can be converted as needed to the more active estradiol. Estrone is the major circulating estrogen in postmenopausal women. In premenopausal women, estrone levels generally parallel those of estradiol, rising gradually during the follicular phase and peaking just prior to ovulation, with a secondary and smaller increase during the luteal phase. After menopause, estrone levels do not decline as dramatically as estradiol levels, possibly due to increased conversion of androstenedione to estrone.

   
Normal range:

   Children: see Table 16.32.

   Adults: see Table 16.33.