Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (912 page)

TABLE 16–32. Reference Intervals for Estrone in Children

TABLE 16–33. Reference Intervals for Estrone in Adults
*

*
Eighteen years of age and older.

   Use

   Diagnosis of precocious and delayed puberty

   Workup of suspected disorders of sex steroid metabolism

   In the fracture risk assessment of postmenopausal women

   Interpretation

Increased In

   Possibly in polycystic ovarian syndrome, androgen-producing tumors, or estrogen-producing tumors.

   Possibly increased in postmenopausal vaginal bleeding due to peripheral conversion of androgenic steroids. Increased estrone levels may be associated with increased levels of circulating androgens and their subsequent peripheral conversion.

Decreased In

   Inherited disorders of sex steroid metabolism

   Testicular feminization

   Limitations

   Significant diurnal variations in plasma levels