Authors: Mary A. Williamson Mt(ascp) Phd,L. Michael Snyder Md
Mineralocorticoids (e.g., fluorocortisone)
High-dose glucocorticoids
High-dose antibiotics (e.g., penicillin, nafcillin, ampicillin, carbenicillin)
Substances with mineralocorticoid effect (e.g., glycyrrhizic acid [licorice], carbenoxolone, gossypol)
Drugs associated with magnesium depletion (e.g., aminoglycosides, cisplatin, amphotericin B, foscarnet)
Acute myelogenous, monomyeloblastic, or lymphoblastic leukemia
Nonrenal causes of excess potassium loss
In patients with hypokalemia, urine potassium levels should be <25 mmol/24 hours. If levels drops to <15 mmol/L it implies extrarenal loss.
GI
Vomiting
Diarrhea (e.g., infections, malabsorption, radiation)
Drugs (e.g., laxatives [phenolphthalein], enemas, cancer therapy)
Neoplasms (e.g., villous adenoma of the colon, pancreatic VIPoma that produces VIP >200 pg/mL, Zollinger-Ellison syndrome)